Which antibiotic should not be given to patients with infectious mononucleosis?

Amoxicillin should not be administered to patients with infectious mononucleosis because it can lead to a distinctive and adverse skin rash. This rash is not an allergic reaction but rather a typical response in individuals with mononucleosis, often caused by the Epstein-Barr virus (EBV). The presence of this rash can create confusion in diagnosis and management, potentially leading healthcare providers to misinterpret it as a drug allergy or a serious adverse reaction, when it is actually a benign but significant effect of the antibiotic in this specific context. By avoiding amoxicillin in these patients, providers can prevent unnecessary complications and ensure appropriate management of the condition. Other antibiotics listed do not have the same associated risks with mononucleosis, making them safer alternatives in such situations.